FIGURE

Fig. 5

ID

ZDB-FIG-230420-70

Publication

Wang et al., 2023 - Transgenic IDH2^R172K and IDH2^R140Q zebrafish models recapitulated features of human acute myeloid leukemia

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

Single-cell RNA sequencing revealed differentiation blockade and enrichment of leukemia-associated gene signatures in FLT3^ITD and IDH2 double mutant zebrafish.

A Lineage differentiation trajectory and pseudotime (B) analysis for the erythroid lineage, with HSPC-MPP as the starting point. C Quantification of the pseudotime values of the erythroid progenitor and erythrocyte (D) in the double mutant and wildtype zebrafish. E Lineage differentiation trajectory and pseudotime (F) analysis for the myeloid lineage, with HSPC-MPP as the starting point. G Quantification of the pseudotime values of the myeloid progenitor and neutrophil (H) in the double mutant and WT zebrafish. I Differentially enriched Hallmark and C2 pathway signatures within the HSC, HSPC-MPP, myeloid, and erythroid progenitor clusters between Tg(Runx1:FLT3^ITDIDH2^R140Q) and WT or Tg(Runx1:FLT3^ITDIDH2^R172K) and WT. Wilcoxon Rank Sum test was performed for C, D, G, and H, ****P < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Oncogene