FIGURE

FIGURE 9

ID

ZDB-FIG-230321-26

Publication

Brown-Panton et al., 2023 - Gap junction Delta-2b (gjd2b/Cx35.1) depletion causes hyperopia and visual-motor deficiencies in the zebrafish

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FIGURE 9

Gjd2b ^?/?/Cx35.1^?/? Light-ON VMR Hyperactivity is Reversed with Rod Photoreceptor Recruitment via Mesopic Light Exposure. (A) General overview of the mesopic VMR Assay. Zebrafish larvae were exposed to 5% light intensity to determine their sensitivity to mesopic vision. (B?C) Light-ON responses revealed that the recruitment of rod-PRC activity reversed the burst hyperactivity previously seen in gjd2b ^?/?/Cx35.1^?/? Light-ON VMR responses. (D?E) Light-OFF responses were reduced in gjd2b ^?/?/Cx35.1^?/? larvae. The statistical significance was determined by the Mann-Whitney test, p ? 0.05. The sample size (N) was 48 for WT and gjd2b ^?/?/Cx35.1^?/? larvae.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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