FIGURE

Figure 5

ID

ZDB-FIG-230314-31

Publication

Zhou et al., 2023 - The apatinib and pemetrexed combination has antitumor and antiangiogenic effects against NSCLC

Other Figures

All Figure Page

Back to All Figure Page

Figure 5

Effect of apatinib combined with pemetrexed on signaling pathways in zebrafish models. (a) Endogenous VEGFaa, VEGFR2, and VEGFR1 in control and lead compounds treated embryos were assessed by qRT-PCR (n = 10?15 individual embryos). APT, apatinib; PEM, pemetrexed; ns, not significant. (b) Endogenous Dll4, Notch1a, Hey2, and EFNB2A in control and lead compounds treated embryos were assessed by qRT-PCR (n = 10?15 individual embryos). (c) Endogenous SLIT2, SLIT3, ROBO1, ROBO2, and ROBO4 in control and lead compounds treated embryos were assessed by qRT-PCR (n = 10?15 individual embryos). (d) Endogenous FGFR11, FGFR 2, FGFR 3, and FGFR 4 in control and lead compounds treated embryos were assessed by qRT-PCR (n = 10?15 individual embryos). Zebrafish strain: Tg (fli1a:EGFP)y1. Animal number: 90 embryos for each condition.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Open Life Sci