FIGURE

Figure 7

ID

ZDB-FIG-221226-321

Publication

Bandla et al., 2022 - A New Transgenic Tool to Study the Ret Signaling Pathway in the Enteric Nervous System

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Figure 7

ret and sox10 mutants lack GFP⁺ ENS cells. (A–A”) In 6 dpf wildtype siblings (wt sibs), GFP⁺ cells colocalize with the pan-neuronal markers Elavl and acetylated Tubulin (AT, white arrows) in ENS neurons; Elavl⁻/AT⁻/GFP⁺ cells with a characteristic teardrop shape are enteroendocrine cells (green arrow). In 6 dpf ret (B–B”) or sox10 (C–C”) homozygous mutants, GFP⁺ ENS neurons are absent. AT⁺ processes are the vagal innervation to the gut (magenta arrows). Elavl⁻/AT⁻/GFP⁺ enteroendocrine cells are still present (green arrows). We analyzed ≥30 larvae per genotype. (A–C), maximum projections of dissected guts. Scale bar = 100 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ret^{hu2846/hu2846}; b1331Tg sox10^t3/t3; b1331Tg
Observed In:	enteric neuron enteroendocrine cell
Stage:	Day 6

Phenotype Detail

Acknowledgments

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