FIGURE

Fig. 1

ID

ZDB-FIG-221221-11

Publication

Chen et al., 2021 - Cell-Penetrating Delivery of Nitric Oxide by Biocompatible Dinitrosyl Iron Complex and Its Dermato-Physiological Implications

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Fig. 1

Kinetics and efficacy study of NO-release reactivity of [Fe₂(μ-SCH₂CH₂COOH)₂(NO)₄] (DNIC-2). Time-dependent change of UV-vis spectra for DNIC-2 in MEM (a) with and (b) without the presence of 10% FBS. The arrows indicate the time-dependent change of the UV-vis spectra. (c) Decompositions of DNIC-2 in MEM with (black) and without (blue) the presence of 10% FBS, respectively, which were fitted to pseudo-first-order kinetics. Data show the mean ± SD from three independent experiments. (d) Half-life for decomposition of DNIC-2 in MEM with or without the presence of 10% FBS at 37 °C. Data represent the mean ± SD (n = 3). (e) Equivalent of released nitric oxide during degradation of DNIC-2. The data are the mean values ± SD pooled from six independent experiments. (f) Time-dependent change of relative fluorescence intensity of NO-specific probe DAF-FM (excitation at 495 nm and emission at 535 nm) with the treatment of 50 μM of DNIC-2 (black) or 133 μM of NONOate (red) in MEM with 10% FBS, which were fitted to pseudo-first-order kinetics. Data show the mean ± SD from three independent experiments. (g) EPR spectra for DNIC-2 in MEM with (black) and without (blue) the presence of 10% FBS, respectively.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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