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Fig. 3

ID

ZDB-FIG-221120-4

Publication

Hayden et al., 2021 - Mathematical modeling of Erk activity waves in regenerating zebrafish scales

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Fig. 3

Figure 3. Variations in model type and assumptions. (A and B) Erk activity as a function of time in two models of wave generation at the source region. Dashed lines indicate the boundary of the source region. The standard model with a constant (A) or oscillatory (B) activator deposition in the source region is shown. (C and D) In silico Erk inhibition and recovery experiment. Pharmacological inhibition is implemented in our model by setting α1 to 0 for the duration of the treatment. (E and F) Alternative wave propagation model in which the Erk inhibitor diffuses. (E) Example of stationary pattern established after 200 h of simulation time. (F) Wave peak speed as a function of activator and inhibitor diffusion constants relative to value of the activator diffusion constant in the standard simulation. Scale bars, 250 μm. To see this figure in color, go online.

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