Figure 4
- ID
- ZDB-FIG-221118-119
- Publication
- Sebo et al., 2022 - Functional identification of the zebrafish Interleukin-1 receptor in an embryonic model of Il-1β-induced systemic inflammation
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Survival analysis of Il-1β-induced mortality. (A) Kaplan-Meier representations of the survival of WT larvae left untreated (WT Uninj No Teb), or Teb treated (WT Uninj + 1 µM Teb), ubb:Gal4-EcR, uas:Ilβmat larvae with no Teb treatment (ubb/uas Uninj No Teb), with Teb (ubb/uas Uninj + 1 µM Teb), or injected with control morpholino with Teb (ubb/uas Con MO + 1 µM Teb). (B) Kaplan-Meier representations of the survival of ubb:Gal4-EcR, uas:Ilβmat larvae left uninjected with teb treatment (ubb/uas Uninj + 1 µM Teb) injected with the cabz splice donor morpholino with Teb (ubb/uas cabz Spl + 1 µM Teb), zmp splice donor morpholino with Teb (ubb/uas zmp Spl + 1 µ M Teb), or zmp start site morpholino with Teb (ubb/uas zmp ATG + 1 µM Teb). Teb was added to the embryos at 1 dpf (red arrowhead). Note that only the zmp morpholinos rescued Il-1β-induced death. ***p<0.001. |
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| Stage: | Protruding-mouth |