FIGURE

Fig. 10

ID

ZDB-FIG-221114-24

Publication

Harms et al., 2021 - An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation

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Fig. 10

EPI-X4 JM#21 prevents immune cell infiltration into lungs in a mouse model of airway hypereosinophilia. (A) BALB/c mice were sensitized intraperitoneal (i.p.) with a mixture containing 50 μg OVA and 2 mg alum in 0.2 mL saline on day 0, 1 and 2. Mice were treated by intranasal (i.n.) administration with JM#21 (16 μmol/kg), EPI-X4 (16 μmol/kg), ALB409-423 (16 μmol/kg) or AMD3100 (12.6 μmol/kg), 2 h before each OVA or saline challenge on Day 5, 6 and 7. Mice were used for OVA-challenged groups (n = 4–6) and unchallenged controls (n = 2). Number of cells infiltrated into BAL were measured by flow cytometry, (B) all cells; (C) eosinophils; (D) T cells; (E) B cells; (F) neutrophils and (G) macrophages. Data were represented as means ± SEM. ^#P ≤ 0.05, ^##P ≤ 0.01 compared to unchallenged control group, and ∗P ≤ 0.05, ∗∗P ≤ 0.01 compared to CTR + OVA group.

Expression Data

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Antibody Labeling

Phenotype Data

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