FIGURE

Fig. 7

ID

ZDB-FIG-221113-7

Publication

Van Dycke et al., 2021 - A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo

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Fig. 7

Molecular docking of compound 10d in the GI.1 and GII.4 norovirus 3CL protease. (A) The binding mode of 10d at the substrate-binding site of the GI.1 norovirus 3CL^pro (PDB code: 3UR9). The GI.1 norovirus 3CL^pro was shown as molecular surface and 10d was shown by green sticks. (B) Interactions of 10d with the surrounding residues. Residues are shown as light green lines, and H-bonds are represented by yellow dashed lines. (C) The binding mode of 10d at the substrate-binding site of the GII.4 norovirus 3CL^pro (PDB code: 6NIR). (D) Interactions of 10d with the surrounding residues. The Schrödinger program (Maestro covalent docking) was used for calculations and PyMOL program for visualizations.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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