FIGURE

Fig. 1

ID

ZDB-FIG-221101-33

Publication

Angom et al., 2021 - LCC-09, a Novel Salicylanilide Derivative, Exerts Anti-Inflammatory Effect in Vascular Endothelial Cells

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Fig. 1

LCC-09 reduces TNFα-induced leukocyte adhesion on endothelial cells. (A) Chemical structure of LCC-09. (B–D) HUVECs were pre-treated with LCC-09 or control DMSO vehicle control for 30 mins at the indicated concentrations and then stimulated with TNFα (5 ng/mL) for 6 h. qPCR was performed (N=4 per group) and expressed as relative folds of control group, which was normalized to 1. (E and F) HUVECs were co-cultured with LCC-09 (5 μM) or DMSO vehicle control for 30 mins and then stimulated with TNFα (5 ng/mL) for 20 h. Then HUVECs were co-cultured with CMFDA-labeled monocytic THP1 cells for 30 mins and adhered monocytes were imaged (D) and counted (E). *p<0.05; **p<0.01.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Inflamm Res