FIGURE

Fig. 6

ID

ZDB-FIG-220912-117

Publication

Wang et al., 2022 - Tankyrase Inhibition Attenuates Cardiac Dilatation and Dysfunction in Ischemic Heart Failure

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Fig. 6

Tnks1 and Tnks2 display a distinct expression pattern in zebrafish developing and adult hearts. (A?C) Confocal images of whole-mount immunostaining for Mhc (A) and Tnks1 (B) in dissected zebrafish heart at 4 dpf. Tnks1 is co-expressed with Mhc in the ventricle (arrowhead) and atrium (arrowhead): A, atrium; V, ventricle; BA, bulbus arteriosus; AVC, atrioventricular canal. (D?F) Representative confocal images of whole-mount immunostaining for Raldh2 (D) and Tnks2 (E) in dissected zebrafish heart at 4 dpf. Tnks2 is co-expressed with Radldh2 in the epicardium (arrowhead). (G?I) Representative immunostaining of adult heart sections from transgenic zebrafish Tg(cmlc2:GFP) for Tnks1 (in red) in ventricle (G), atrium (H), and bulbus arteriosus (I). The Tnks1-positive signal is seen in the coronary vasculature (CV) and blood cell (BC) in the lumen. (J?L) Representative immunostaining of adult heart sections from transgenic zebrafish Tg(cmlc2:eGFP) for Tnks2 (in red) in ventricle (J), atrium (K), and bulbus arteriosus (L). The Tnks2-positive signal is seen in the epicardium (EP), the nucleus of the trabecular and cortical cardiomyocytes (arrowhead), and the coronary vasculature (CV). Scale bars: 20 ?m.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.