FIGURE

Fig. 3

ID

ZDB-FIG-220824-63

Publication

Halabi et al., 2022 - Semaphorin3f as a cardiomyocyte derived regulator of heart chamber development

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Fig. 3

sema3fb mutant embryos have reduced cardiac function. A, B Still images from videos of beating WT and sema3fb^ca305 mutant hearts at 72 hpf. Ventricle measurements were made in both the long axis (white line, L: length) and short axis (black line, W: width) to determine ventricle volumes. ba: bulbus arteriosus. C, D Quantitation of the average ventricle volume at end diastole (C) and end systole (D) reveals a significantly decreased capacity in the sema3fb mutant (p = 0.0027 and p = 0.0063, respectively) as compared to WT. E-I Graphs showing average heart rate (p = 0.0008) (E), cardiac output (p = 0.026) (F), stroke volume (p = 0.033) (G), ejection fraction (p = 0.45) (H), and fractional shortening (p = 0.17) (I). (N = 3; n = 12 sema3fb^+/+, n = 20 sema3fb^ca305). Scale Bar: 100 µm

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sema3fb^ca305/ca305
Observed In:	cardiac ventricle heart contraction
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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