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Graphical Abstract

ID
ZDB-FIG-220717-20
Publication
Arora et al., 2022 - Development of a Multicellular 3D Tumor Model to Study Cellular Heterogeneity and Plasticity in NSCLC Tumor Microenvironment
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Graphical Abstract

Schematic representation of multicellular 3D tumor spheroid with distinct proliferative and necrotic zones exhibiting key features of TME such as heterogeneity, cancer cell reprogramming and stemness, aggressive phenotype, alteration of stromal cells plasticity, and tumor angiogenesis. Results obtained from the study of 3D tumor spheroids were validated in the in-vivo experiments with zebrafish tumor xenograft model and lung cancer patients tissue samples.

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Acknowledgments
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