FIGURE

Fig. 4

ID

ZDB-FIG-220630-39

Publication

Reurink et al., 2022 - Scrutinizing pathogenicity of the USH2A c.2276 G > T; p.(Cys759Phe) variant

Other Figures

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Fig. 4

Rhodopsin localization to the photoreceptor cell body in the ush2a^{p.(Cys771Phe)} zebrafish.

a Rhodopsin (green signal) localizes to the rod photoreceptor outer segments in wildtype larval eyes. A visual representation of a photoreceptor is shown on the right. b Aberrant localization of rhodopsin to the photoreceptor cell body was observed in ush2a^{p.(Cys771Phe)} larvae (indicated by white arrows), which was observed in a significantly higher number of photoreceptors of ush2a^{p.(Cys771Phe)} larvae as compared to wildtype larvae (c; unpaired t test). Nuclei are stained with DAPI (blue signal). Scale bar: 10?µM. ****p?<?0.0001.

Expression Data

Antibody:	Ab5-rho
Fish:	TL ush2a^{rmc016Tg/rmc016Tg} (TL)
Anatomical Terms:	retinal rod cell cell body retinal rod cell rod photoreceptor outer segment
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ush2a^{rmc016Tg/rmc016Tg} (TL)
Observed In:	retinal rod cell cell body
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ NPJ Genom Med