FIGURE

Figure 2

ID

ZDB-FIG-220518-112

Publication

Sun et al., 2022 - Notch-Sox9 Axis Mediates Hepatocyte Dedifferentiation in Kras^G12V-Induced Zebrafish Hepatocellular Carcinoma

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Figure 2

Zebrafish hepatocytes undergo dedifferentiation and biliary duct activation after kras^G12V induction. (A) Whole-mount in situ hybridization (WISH) results showed the expression pattern of sox9b, hhex, and foxa3 at 6 dpf, 8 dpf, and 10 dpf, respectively, after DOX activation of kras^G12V. (B,C) Antibody staining of biliary duct marker Anxa4 in zebrafish liver expression at 6 dpf, 8 dpf, and 10 dpf after DOX induction, and statistics of Anxa4+ area in the liver in the control (n = 10) and kras^G12V+ (n = 11) groups. Numbers indicate the percentage of larvae exhibiting this expression. Asterisks show significance: *—p < 0.05; ***—p < 0.001; ****—p < 0.0001. Scale bars—100 μm; error bars—S.D.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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