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Fig. 1

ID

ZDB-FIG-220516-50

Publication

Thiagarajan et al., 2022 - Receptor-Mediated AKT/PI3K Signalling and Behavioural Alterations in Zebrafish Larvae Reveal Association between Schizophrenia and Opioid Use Disorder

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Fig. 1

Figure 1. Experimental design schematics. (A) Embryos at 48 hpf were treated to obtain the MTC of the drugs. (B) Exposure timeline of the drugs. (C) Synaptic localization of all genes examined. (D) Aggression testing using a test tank with a mirror. ADAMTS2: a disintegrin and metalloproteinase with thrombospondin motifs 2, AKT1: v-akt murine thymoma viral oncogene homolog 1, AMPA: ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, CREB: cAMP responsive element binding protein, DA: dopamine, dpf: days post fertilization, hpf: hours post fertilization, MTC: maximum tolerated concentration, NMDA: N-methyl-D-aspartate, PI3K: phosphoinositide 3-kinase, SLC6A4: solute carrier family 6 member 4, 5-HT: 5-hydroxytryptamine.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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