FIGURE

FIGURE 7

ID

ZDB-FIG-220430-27

Publication

Wu et al., 2022 - miR-29b-3p Inhibitor Alleviates Hypomethylation-Related Aberrations Through a Feedback Loop Between miR-29b-3p and DNA Methylation in Cardiomyocytes

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FIGURE 7

The impact of miR-29b-3p inhibitor on the overall development of hypomethylated zebrafish embryos. (A) miR-29b-3p inhibitor partially reduced the mortality and deformity rates of zebrafish that resulted from 5-azacytidine exposure (n > 100). (B–D) The zebrafish general development score of the miR-29b-3p inhibitor group was significantly better than that of the NC inhibitor group at 48 hpf and 72 hpf (n > 50). (E and F) The heart rate and fractional shortening of zebrafish embryos coinjected with 5-azacytidine and miR-29b-3p inhibitor displayed no significant difference from those of the 5-azacytidine and NC inhibitor groups (n = 20).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Conditions:	chemical treatment by environment: 5-azacytidine chemical treatment by environment: 5-aza-2'-deoxycytidine
Observed In:	embryo development whole organism
Stage Range:	Long-pec to Protruding-mouth

Phenotype Detail

Acknowledgments

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