FIGURE

Figure 6

ID

ZDB-FIG-220406-60

Publication

Baek et al., 2022 - Vascular Injury in the Zebrafish Tail Modulates Blood Flow and Peak Wall Shear Stress to Restore Embryonic Circular Network

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Figure 6

WSS-responsive Notch-ephrinb2 pathway regulates arterial network formation. (A) Injection of ephrinb2 MO (0.5-1mM) diminished flt1⁺ in the amputated site (white arrowheads) to attenuate loop formation at 4 dpa (white arrow). Transient overexpression of ephrinb2 mRNA promoted flt1⁺ network formation in the amputated site (white arrowheads) and restored DAPT and DN-Notch1b mRNA-impaired flt1⁺ regeneration (white arrow) (n = 20 per group). Scale bar: 20 μm. (B) Schematic representations of ephrinb2-dependent flt1⁺ and flt14⁺ regeneration. Black arrowheads depict regenerated flt1⁺ (Red) and flt4⁺ (Blue) in response to differential ephrinb2 expressions.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cardiovasc Med