FIGURE

FIGURE 4

ID

ZDB-FIG-220406-29

Publication

Xie et al., 2022 - Emodin Protects Against Lipopolysaccharide-Induced Acute Lung Injury via the JNK/Nur77/c-Jun Signaling Pathway

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FIGURE 4

Emodin suppresses LPS-induced activation of c-Jun through regulation of Nur77. (A) Emodin decreases the expression levels of p-c-Jun (Ser73) and c-Jun through regulation of Nur77. RAW264.7 cells were transfected with Nur77 siRNA (120 nM) for 24 h, and then treated with emodin (40 μM) for 2 h, followed by exposure to LPS (100 ng/ml) for another 18 h, p-c-Jun (Ser73), and c-Jun were detected by Western blotting. (B) Emodin inhibits the DNA-binding activity of c-Jun through regulation of Nur77. The nuclear lysates were harvested and the DNA-binding activity were measured using EMSA.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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