A Manhattan plot for RLS association in patients with migraine. Manhattan plot of the discovery genome-wide association analysis of 115 cases and 635 controls. The x axis is chromosomal position, and the y axis is the significance (–log10 P) of association derived from Cochran–Armitage trend tests. B Quantile–quantile plot of results from the Cochran-Mantel–Haenszel analysis. Red line represents the distribution of P values under the null hypothesis, given a study inflation factor (λ) of 1.000
|