FIGURE

Figure 6—figure supplement 1.

ID

ZDB-FIG-220326-38

Publication

Ahmed et al., 2022 - Strip1 regulates retinal ganglion cell survival by suppressing Jun-mediated apoptosis to promote retinal neural circuit formation

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Figure 6—figure supplement 1.

Gene ontology (GO) enrichment analysis of differentially expressed genes (DEGs) from RNA-seq of <italic toggle='yes'>strip1</italic> mutants and comparison between upregulated DEGs in <italic toggle='yes'>strip1</italic> mutant transcriptomes vs. transcriptomes of zebrafish retinal ganglion cells (RGCs) under stress.

List of enriched GO terms in DEGs downregulated (A) and upregulated (B) in strip1^rw147 mutant relative to wild-type siblings as analyzed with Metascape, FDR < 0.05 and log₂ FC > |1|. Downregulated genes show many GO terms related to the nervous system, RGCs, embryo morphogenesis, synaptic development, and transmission. Upregulated genes show terms related to stress response, cell death and MAPK signaling. (C) Venn diagram showing overlap of upregulated DEGs in RNA sequencing datasets of strip1^rw147 mutant relative to wild-type (FDR < 0.05 and FC > 1.5) in comparison with published upregulated DEGs in microarray data of adult zebrafish RGCs at 3 days post-optic nerve injury (ONI) (Veldman et al., 2007) and adult zebrafish eyes at 4 days post-optic nerve crush (ONX) (McCurley and Callard, 2010).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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