FIGURE

Fig. 3

ID

ZDB-FIG-220131-65

Publication

McTiernan et al., 2021 - NAA10 p.(N101K) disrupts N-terminal acetyltransferase complex NatA and is associated with developmental delay and hemihypertrophy

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Fig. 3

NAA10 multiple sequence alignment and NatA structural analysis.

a Multiple sequence alignment of NAA10 orthologues from human, mouse, rat, zebrafish, frog, and yeast. Secondary structure was determined from hNatA structure (PDB ID: 6C9M) [40] and amino acid conservation is indicated by red colour. b Human NatA structure (PDB ID: 6C9M) [40] with the auxiliary subunit NAA15 (grey), the catalytic subunit NAA10 (green) and Ac-CoA and IP₆ shown as orange and blue sticks, respectively. The structure was superimposed on Ac-CoA from the S. pombe NAA10 structure (PDB ID: 4KVX) [13]. The variant site Asn101 is coloured red. Close-up of Asn101 shows that it is located in NAA10 α3 helix with its side chain protruding toward NAA15.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Eur. J. Hum. Genet.