FIGURE

Figure 2

ID

ZDB-FIG-220131-375

Publication

La Spina et al., 2021 - Multiple Mechanisms Converging on Transcription Factor EB Activation by the Natural Phenol Pterostilbene

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Figure 2

Pt elicits mitochondrial superoxide generation in HeLa cells. (a) MitoSOX? fluorescence response elicited by Pt. The cells in curves iv) and v) were pretreated, respectively, with 1 mM NAC (60 min) or 5 ?M BAPTA-AM (20 min), and continued to be incubated with these agents also during treatment with Pt. The arrow indicates the addition of Pt. Mean values + SEM. (b) NAC antagonizes Pt-induced TFEB migration to the nucleus. TFEB migration in HeLa cells exposed to the indicated conditions for 3 hours. Mean values + SEM. N > 53 cells for each tested condition, from at least 4 separate experiments. (c) Pt inhibits Complex I activity in permeabilized RLM. Mean values + SEM; N = 6.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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