FIGURE

Figure 4

ID

ZDB-FIG-220131-182

Publication

Ahuja et al., 2022 - Myocardial Afterload Is a Key Biomechanical Regulator of Atrioventricular Myocyte Differentiation in Zebrafish

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Figure 4

Increased afterload increases retrograde flow and alters AVJ mechanics. (A) Diameter of the flow field at the atrioventricular junction in control hearts at 56 hpf. X–axis is normalized time across a cardiac cycle, where 0 corresponds to the beginning of atrial contraction and 1 represents the end of ventricular contraction. n = 4 (B) Diameter analysis of vaso-treated hearts that showed hypertrophic growth between 40 and 56 hpf. n = 6 (C) Diameter analysis of vaso-treated hearts at 56 hpf. These hearts showed severely altered pumping mechanics at 40 hpf. (D) Maximum diameter analysis of control, vaso-treated hearts that showed altered pumping (AP) and vaso-treated hearts that showed hypertrophic growth (HH). (E) Retrograde flow fraction (RFF) at 40 and 56 hpf in control and vaso-treated hearts. n = 11 control and 12 vaso-treated fish. * indicates p < 0.05.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Cardiovasc Dev Dis