FIGURE

Figure 3

ID

ZDB-FIG-220131-128

Publication

Mech et al., 2022 - Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in Zebrafish

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Figure 3

Differential gene expression analysis. (A) Schematic of the experimental design. Zebrafish were exposed to nicotine, oxycodone and amphetamine or left untreated from 1 to 5 dpf before being collected in six pools of seven larvae per condition for RNA-seq. (B) PCA of samples that passed all quality control checks. Samples from each condition group together. Amphetamine and oxycodone samples are clustered more closely (and so have more similar expression profiles) than nicotine samples. (C) Bar chart showing the number of differentially expressed genes (DEGs) in each drug treatment. Upregulated genes are shown in red and downregulated genes are in blue. (D–F) Volcano plots showing the distribution of DEGs. Genes that are not significant (adjusted p-value ≥ 0.05) are in gray, significant genes (adjusted p-value < 0.05) are in red if upregulated and in blue if downregulated. The top 10 DEGs by p-value are labeled in each plot.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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