FIGURE

Fig. 5

ID

ZDB-FIG-211219-78

Publication

Aneas et al., 2021 - Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region

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Fig. 5

The rs1888909 (T) and rs992969 (A) alleles are associated with increased IL33 expression and IL-33 protein levels.

a Comparison of IL33 expression between genotypes for SNPs rs10975479, rs1888909, and rs992969 from bronchial epithelial cells from 124 asthmatic and non-asthmatic adult subjects, mostly of European ancestry (upper panels) and nasal epithelial cells from 189 African-American children from high risk asthma families (lower panels). b Comparison of IL-33 cytokine levels between genotypes for SNPs rs10975479 (n = 27), rs1888909 (n = 27), and rs992969 (n = 25) measured in plasma from Hutterite children (all European ancestry). The asthma-associated risk allele at each SNP is highlighted in red (x-axis). The number of subjects per group is shown below the genotype. Boxplot center line: median; box limits: upper and lower quartiles; whiskers: 1.5× interquartile range. Statistical significance was determined using an additive linear model. Source data are provided as a Source Data file.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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