FIGURE

FIGURE 4

ID

ZDB-FIG-211216-141

Publication

Chen et al., 2021 - Alginate-Capped Silver Nanoparticles as a Potent Anti-mycobacterial Agent Against Mycobacterium tuberculosis

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FIGURE 4

ALG-AgNPs significantly inhibit the growth of cytosolic Mycobacterium tuberculosis in a macrophage infection model. (A) Schematic diagram of the experimental procedures. (B–E) THP-1 cells were differentiated into macrophages by PMA stimulation for 3 days, then infected with different strains of Mtb at a MOI of 1 for 24 h. After treatment with PBS, or different amounts of ALG-AgNPs (25, 50, and 100 μg/ml), or rifampicin (RIF) (1 μg/ml) for 5 days, the cells were lysed and plated on 7H10 agar plates. The bacterial growth was determined by CFU of (B) H37Rv, (C) W6 (Beijing strain), (D) KVGH264 (MDR), and (E) TCHL017 (XDR). MDR: Multidrug-resistant TB; XDR: extensively drug-resistant TB. Data represent mean ± SEM of 3 experiments. ***p < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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