FIGURE 5

Clinical data show the abnormal serum testosterone level of mental disorder patients. We collected the medical records of patients with mental disorder in the hospital. Among 2,579 male patients (A) and 3,926 female patients (C) aged 20–49 years, the testosterone level in their serum was tested. Among the patients over the age of 50, the proportion of abnormal testosterone levels among 1,009 men (B) suffering from anxiety, insomnia, and depression was significantly increased (E–G), but among 1,741 women (D) suffering from anxiety, insomnia, and depression, the proportion of abnormal testosterone levels is significantly reduced. (E) For five male patients with schizophrenia who are known to have ATRN mutations in the clinic, their lower serum testosterone levels are more than that of schizophrenia patients without ATRN mutations. (F) For nine female schizophrenia patients with ATRN mutations, serum testosterone level was higher than that of the schizophrenia patients without ATRN mutations. Chi-test (Fisher’s exact test). *p < 0.05; **p < 0.01; ***p < 0.001; ns, no significance (p > 0.05).