FIGURE

Figure 3

ID

ZDB-FIG-211029-137

Publication

Lam et al., 2021 - Systems Analysis Reveals Ageing-Related Perturbations in Retinoids and Sex Hormones in Alzheimer's and Parkinson's Diseases

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Figure 3

Metabolic characterisation of AD and PD subclasses. Flux balance analysis (FBA) was performed on iADPD1-3 genome-scale metabolic models (GEMs), and flux values were compared with those of iADPDControl. Key metabolites and reactions within the androgen metabolism pathway are shown and key dysregulations are displayed as coloured arrows: red indicates increased flux compared to iADPDControl; blue indicates decreased flux compared to iADPDControl. Dysregulations associated to each GEM are shown in coloured boxes. The dashed line indicates multiple reactions are involved. Human Metabolic Reactions (HMR) identifiers are shown for androgen metabolism reactions with dysregulated fluxes. For full data, refer to Supplementary Data S2.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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