FIGURE
Figure 7
- ID
- ZDB-FIG-211002-76
- Publication
- Lu et al., 2021 - Exacerbation of Liver Tumor Metastasis in twist1a+/xmrk+ Double Transgenic Zebrafish following Lipopolysaccharide or Dextran Sulphate Sodium Exposure
- Other Figures
- All Figure Page
- Back to All Figure Page
Figure 7
Figure 7. Exposure to LPS or DSS exacerbated the increase in liver size and HCC progression in xmrk+ zebrafish. (A) Quantification and (B) representative images of liver size in xmrk+, xmrk+/LPS, and xmrk+/DSS zebrafish larvae as well as xmrk- siblings at 3 dpt. (C) xmrk+, xmrk+/LPS, and xmrk+/DSS transgenic zebrafish as well as xmrk- control transgenic zebrafish were treated at 4 mpf with 20 μg/mL Dox plus 40 ng/mL LPS or 0.5% DSS, with samples taken at 2 wpi. The left column shows internal abdominal organs with the livers outlined, and the right column depicts H&E staining of liver sections. Scale bar: 50 or 200 μm. (D) Kaplan–Meier survival curves showing days post-induction plotted against percentage survival to 2 wpi. (E) Histological examination confirmed that xmrk+, xmrk+/LPS, and xmrk+/DSS transgenic zebrafish developed HCC at 2 wpi, compared to normal liver histology in xmrk- siblings. Differences among the variables were assessed using Student’s t-tests or one-way ANOVA. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001.
|
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
| Fish: | |
|---|---|
| Conditions: | |
| Observed In: | |
| Stage: | Adult |
Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ Pharmaceuticals (Basel)