FIGURE

FIGURE 4

ID

ZDB-FIG-210929-16

Publication

Liu et al., 2021 - Social Deficits and Repetitive Behaviors Are Improved by Early Postnatal Low-Dose VPA Intervention in a Novel shank3-Deficient Zebrafish Model

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FIGURE 4

shank3 deficiency resulted in the reduction of synapse-related proteins in adult zebrafish brain. (A,B) Quantitative immunoblot blot analysis showed that the neuron protein NeuN was significantly decreased (50% of WT) in the shank3ab^{– /–} male zebrafish brain relative to WT zebrafish (3.5 mpf). (C,D) The expression of post-synaptic homer1 protein was markedly reduced in shank3ab^{– /–} male zebrafish brain compared with that of WT zebrafish (3.5 mpf, 10% of WT). (E,F) The expression of presynaptic synaptophysin protein was significantly reduced in shank3ab^{– /–} male zebrafish brain compared with that of WT zebrafish (3.5 mpf, 36% of WT). N = 3 for each group. Data are presented as mean ± SEM; *P < 0.05, **P < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Neurosci.