FIGURE

Fig 4

ID

ZDB-FIG-210926-19

Publication

Suzzi et al., 2021 - Deletion of lrrk2 causes early developmental abnormalities and age-dependent increase of monoamine catabolism in the zebrafish brain

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Fig 4

Age-dependent perturbation of monoamine catabolism in the mzLrrk2 brain.

(A) Simplified scheme of the catabolism of dopamine and serotonin in the zebrafish brain. Each arrow represents a distinct enzymatically-catalyzed step. Grey arrows indicate the reactions catalyzed by the combined action of monoamine oxidase (MAO)/aldehyde dehydrogenase. Abbreviations: 3-MT, 3-methoxytyramine; 5-HIAA, 5-hydroxyindoleacetic acid; 5-HT, serotonin; DA, dopamine; DOPA, 3,4-dihydroxyphenylacetic acid; HVA, homovanillic acid; NA, noradrenalin. (B-H) Levels of biogenic amines and their catabolites in the brain of adult maternal-zygotic tud113 fish at different ages: 4, 6, 8, and 11 months, and age-matched controls; data from 2.5-year-old (yo) maternal-zygotic tud112 fish, and age-matched controls, are also included. Plots represent means ± s.e.m. Statistical analyses: (B: 4–6 mo, B: 11 mo, C: 6 mo, C: 11 mo, C: 2.5 yo, D-G: 6–11 mo, G: 2.5 yo, H) two-tailed Student’s t-test; (B: 8 mo, B: 2.5 yo, C: 4 mo, C: 8 mo, G: 4 mo) two-tailed Mann-Whitney’s U-test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lrrk2^{tud113/tud113}
Observed In:	brain dopamine biosynthetic process brain monoamine oxidase activity brain serotonin biosynthetic process
Stage:	Adult

Phenotype Detail

Acknowledgments

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