FIGURE

Fig. 6

ID

ZDB-FIG-210725-22

Publication

Wang et al., 2021 - Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis

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Fig. 6

Loss of p63 (not p53 and p73) partially rescued Thaps. induced apoptosis at early embryonic stage.

A Loss of p63 partially rescued Thaps. induced apoptosis at 24 hpf. Ratio of phenotypic categories of the apoptotic severity in wild type, tp63^−/−, sibling tp63^+/− and sibling tp63^+/+ zebrafish embryos at 4 h after DMSO or Thaps. treatment. Embryos from the intercross of heterozygous-mutant tp63 adults were genotyped after sorted based on the apoptotic severity at tail region. B Loss of p53 and p73 cannot rescue Thaps. induced apoptosis at 24 hpf. Ratio of phenotypic categories in 24 hpf wild-type and tp53^−/− tp73^−/− zebrafish embryos at 4h after DMSO or Thaps. treatment. n = 6 (A) and n = 4 (B) from pooled embryos per sample. The total number of Thaps treated embryos: wild type > 660, tp63^−/− > 360, tp63^+/− > 700, tp63^+/+ > 320 and tp53^−/− tp73^−/− > 420. Bars represent mean ± SEM. ****p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT tp63^uab7/uab7 tp73^uab8/uab8; tp53^uab6/uab6
Condition:	chemical treatment by environment: thapsigargin
Observed In:	whole organism apoptotic process
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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