FIGURE

Fig. 1

ID

ZDB-FIG-210716-94

Publication

Zhou et al., 2015 - The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

(A–D) Nfatc1^Cre;Krit1^fl/fl hearts exhibit thinned myocardium and reduced space between endocardial and myocardial cells at E10.5 and E12.5. Arrows indicate the endocardial-myocardial gap. (A′-D′) Higher magnification images of the regions boxed in (A)–(D). (E) Ratio of the area occupied by cardiac jelly to that occupied by myocardium in the trabeculae of E10.5 littermate hearts. N = 3 embryos; nine sections analyzed for each group. ∗∗p < 0.01. Error bars represent SEM. (F and G) Reduced Alcian blue staining in Nfatc1^Cre;Krit1^fl/fl hearts at E10.5. (F′ and G′) Higher magnification images of the regions boxed in (F) and (G). (H and I) Immunostaining for versican in Nfatc1^Cre;Krit1^fl/fl and control hearts at E10.5. (H′ and I′) Higher magnification images of the regions boxed in (H) and (I). Scale bars represent 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Cell, 32, Zhou, Z., Rawnsley, D.R., Goddard, L.M., Pan, W., Cao, X.J., Jakus, Z., Zheng, H., Yang, J., Arthur, J.S., Whitehead, K.J., Li, D., Zhou, B., Garcia, B.A., Zheng, X., Kahn, M.L., The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression, 168-80, Copyright (2015) with permission from Elsevier. Full text @ Dev. Cell