FIGURE

Figure 2

ID

ZDB-FIG-210716-88

Publication

Lima Cunha et al., 2021 - REP1-deficiency causes systemic dysfunction of lipid metabolism and oxidative stress in choroideremia

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Figure 2

CHM patients exhibit evidence of increased oxidative stress. (A) Schematic of the glutathione metabolism pathway, where several compounds were found to be increased (red) or decreased (green) in CHM patients compared with controls. Metabolites trending to significance (0.05 < P ≤ 0.1) are represented in a lighter shade to distinguish from those significantly altered (P ≤ 0.05). (B–I) Scatter dot plots of specific metabolites indicating the mean ± SD levels in CHM patient samples (red) and control samples (blue) (n = 25). P value was determined using matched pair t tests. #0.05 < P ≤ 0.1, *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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