FIGURE

Figure 1

ID

ZDB-FIG-210702-8

Publication

Jacobs et al., 2021 - Occurrence of foamy macrophages during the innate response of zebrafish to trypanosome infections

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Figure 1

(A) Tg(mpeg1:mCherry-F;mpx:GFP) larvae (5 dpf) were injected intravenously with n = 200 T. carassii/fish or with PVP as control and survival was monitored over a period of 15 days. (B) Tg(mpeg1:mCherry-F;mpx:GFP) zebrafish (5 dpf) were treated as in A and sampled at various time points. At each time point, three pools of 3–5 larvae were sampled for real-time quantitative PCR analysis. Relative fold change of the T. carassii-specific heat-shock protein-70 (hsp70) was normalised to the zebrafish-specific ef1α and expressed relative to the trypanosome-injected group at time point zero. Bars indicate average and standard deviation (SD) on n = 3 pools per time point. Letters indicate significant differences (p<0.05), as assessed using One-way ANOVA followed by Tukey’s multiple comparisons test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gl22Tg/gl22Tg; ump2Tg/ump2Tg
Conditions:	chemical treatment by environment: poly(vinylpyrrolidone) biological treatment: Trypanosoma carassii
Observed In:	detection of other organism whole organism
Stage Range:	Day 5 to Days 14-20

Phenotype Detail

Acknowledgments

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