FIGURE

Figure 3

ID

ZDB-FIG-210606-162

Publication

Rohrer et al., 2021 - Conditional Loss of the Exocyst Component Exoc5 in Retinal Pigment Epithelium (RPE) Results in RPE Dysfunction, Photoreceptor Cell Degeneration, and Decreased Visual Function

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Figure 3

Immunohistochemical analysis of rod and cone photoreceptors in transgenic (Tg:XOPS) wild-type and exoc5 mutant zebrafish. Top panel: wild-type:Transgenic-XOPS (WT;Tg-XOPS-GFP) zebrafish retinas immunostained with R/G cone opsin (red). Bottom panel: exoc5−/− mutant:Transgenic-XOPS (exoc5−/−;Tg-XOPS-GFP) retinas immunostained with R/G cone opsin (red). The transgenic line expresses soluble endogenous GFP in rods (green). Significantly shorter rod and cone OS were observed in exoc5−/− mutant zebrafish, compared to WT zebrafish, at similar ages. (C) Image J was used to quantify fluorescence for R/G cone opsin and GFP+ rods. ** p < 0.005 (WT vs. exoc5−/− mutants).

Expression Data

Gene:	EGFP
Fish:	fl1Tg (AB/TU) exoc5^{sa23168/sa23168}; fl1Tg (AB/TU)
Anatomical Term:	retinal rod cell
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	exoc5^{sa23168/sa23168}; fl1Tg (AB/TU)
Observed In:	retinal cone cell photoreceptor cell outer segment organization retinal rod cell photoreceptor cell outer segment organization
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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