FIGURE

FIGURE 7

ID

ZDB-FIG-210602-10

Publication

Gourain et al., 2021 - Multi-Dimensional Transcriptome Analysis Reveals Modulation of Cholesterol Metabolism as Highly Integrated Response to Brain Injury

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FIGURE 7

Alternative splicing of RNAs related to cholesterol metabolism in response to injury. (A) Splicing isoforms of RNAs encoding proteins of the cholesterol synthesis and transport pathway were first reconstructed and then quantified in both uninjured and injured telencephalic hemispheres. The color blue depicts a decrease in the number of supporting reads while yellow an increase. A number of splice isoforms were not yet annotated in the genome (unannotated). *adjp = 0.05, **adjp < 10^–02, ***adjp < 10^–03. (B) All results about cholesterol metabolism were finally integrated, including up-regulated transporters (red) down-regulated synthesizing enzymes (green) and genes encoding mRNA affected by alternative splicing (indicated by +) or predicted targets of microRNA or lncRNA (indicated by *). Underlined names depict genes harboring the SRE motif in their 1-kbp promoter.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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