FIGURE

Figure 5

ID

ZDB-FIG-210531-9

Publication

Mathieu et al., 2021 - Genetic variant of TTLL11 gene and subsequent ciliary defects are associated with idiopathic scoliosis in a 5-generation UK family

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Figure 5

Knockdown of ttll11 leads to scoliosis phenotype in zebrafish larvae. Ttll11 knock-down zebrafish showed body curvature phenotype compared to control. (A) Representation of the blocking antisense morpholino oligonucleotide targeting zebrafish ttll11 (NM_001077375.1). (B) Mutant and control zebrafish phenotype (3–5 dpf). (C) Incidence of body axial deformity after MOs injection into fertilised zebrafish eggs at the one- to two-cell stages.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO2-ttll11
Knockdown Reagent:	MO2-ttll11
Observed In:	post-vent region
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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