FIGURE

Fig. 8

ID

ZDB-FIG-210527-8

Publication

Mannucci et al., 2021 - Genotype-phenotype correlations and novel molecular insights into the DHX30-associated neurodevelopmental disorders

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Fig. 8

DHX30 deficiency in zebrafish cells leads to reduced formation of stress granules. a Representative confocal images of TIAL-1-labeled stress granules (green) in dhx30 wild-type (+/+) and homozygous mutants (−/−). Zebrafish underwent normal conditions or heat shock treatment at 42 °C. Nuclei were counterstained with DAPI (blue). b Analyses of TIAL-1-labeled stress granules per 50 nuclei. The total number of embryos assessed are 8, 9, 8, and 8 for dhx30 +/+ (28 °C), dhx30 −/− (28 °C), dhx30 +/+ (42 °C), and dhx30 −/− (42 °C), respectively. Data are presented as means ± standard error of mean based on the indicated number of embryos. ***: significantly different from DHX30+/+ (***p< 0.001; unpaired Student’s t test)

Expression Data

Antibody:	Ab2-tial1
Fish:	AB dhx30^{zf3562/zf3562} (AB)
Condition:	heat shock
Anatomical Term:	head cytoplasmic stress granule
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB dhx30^{zf3562/zf3562} (AB)
Condition:	heat shock
Observed In:	head cytoplasmic stress granule
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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