FIGURE

FIG 5

ID

ZDB-FIG-210524-5

Publication

van der Niet et al., 2021 - IL-1R1-Dependent Signals Improve Control of Cytosolic Virulent Mycobacteria In Vivo

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FIG 5

Early cytosolic localization of M. tuberculosis in SCID mouse lungs. (A and B) Sections of SCID mouse lung tissue infected with M. tuberculosis H37Rv for 21 days were labeled for LAMP1 using immunogold labeling to indicate lysosomes. (A′ and B′) Schematic representations, with orange indicating M. tuberculosis, blue lines indicating host membranes, black dots representing gold particles indicating LAMP1-decorated lysosomes, and green indicating mitochondria. Panel A shows a cross section of M. tuberculosis surrounded by cellular membranes, which is thus phagosomal. Panel B shows M. tuberculosis present in the cytosol, without cellular membranes surrounding the bacteria. For information on the number of imaged bacteria and mice, see Table S1 in the supplemental material.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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