FIGURE

Figure 2

ID

ZDB-FIG-210519-84

Publication

Barbereau et al., 2021 - Zebrafish Models to Study New Pathways in Tauopathies

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Figure 2

Transgenes used to generate stable lines. (1) Human MAPT 4R isoform is expressed under Eno2 promoter [29]. (2) Double transgenic line using Gal4/UAS system: Gal4 is expressed under HuC promoter and bind to bidirectional UAS promoter to induced the expression in the same neuron of DsRed and hTauP301L proteins [30]. (3) Using HuC promoter driving Gal4 line cross with UAS-driven fused Dendra:MAPT or Dendra:MAPTA152T results in neuronal expression of human proteins Dendra-hTauWT or Dendra-hTauAT52T [31]. (4) Conditional transgene using CreERT2_LoxP recombination: tamoxifen incubation results in expression of 2 proteins: EGFP and hTauP301L in her4.1 positive neural stem cells [32]. (5) Retina expression of MAPT or MAPTP301L driven by rhodopsin (Rho) promoter [33,34].

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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