FIGURE

Fig. 2

ID

ZDB-FIG-210426-34

Publication

Mante et al., 2021 - Solid-lipid nanoparticle formulation improves antiseizure action of cryptolepine

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Fig. 2

Effect of cryptolepine and SLN-CRYP on PTZ-induced seizure-like behavior in Zebrafish. Adult Zebrafish were injected (i.p.) with PTZ 10 min after pretreatment with cryptolepine (2.5 and 5 mg/kg), SLN-CRYP (2.5 and 5 mg/kg), diazepam (2 mg/kg). They were transferred to a 15 L observation tank containing water up to three-quarters of its capacity. After recovery from anesthesia, the zebraﬁsh behavior was recorded for a period of 10 min. The recording was scored for the A) Latency to seizure onset (s) B) mean maximum seizure score over 600 s for each group C) Total distance swam over 600 s D) Time spent in the lower and upper zones of the fish tank for each group (s). Data are expressed as Mean ± S.E.M, n = 10, analyzed by A) two-way ANOVA and B) one-way ANOVA, followed by Tukey test *P < 0.05, **P < 0.01 and ***P < 0.001 in comparison to the negative control (PTZ) group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	chemical treatment by injection: pentetrazol
Observed In:	adult locomotory behavior
Stage:	Adult

Phenotype Detail

Acknowledgments

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