FIGURE
Fig. 2
- ID
- ZDB-FIG-210414-34
- Publication
- Zheng et al., 2021 - Molecular regulation of myocardial proliferation and regeneration
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Fig. 2
Working model of injury-induced cardiomyocyte proliferation. Injury signals trigger the cell-cycle re-entry of CMs, leading to the formation of mononuclear, polynuclear, or polyploidy CMs. De-differentiation signals together with extracellular matrix (ECM) re-organization then regulate the generation of putative de-differentiated CMs, which have evident changes in mitochondrial morphology, disassembled sarcomeres, and reduced cell adhesion. Finally, reprogramming signals and mitogens drive the formation of putative progenitors and cell division |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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