FIGURE

Fig. 2

ID
ZDB-FIG-210414-34
Publication
Zheng et al., 2021 - Molecular regulation of myocardial proliferation and regeneration
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Fig. 2

Working model of injury-induced cardiomyocyte proliferation. Injury signals trigger the cell-cycle re-entry of CMs, leading to the formation of mononuclear, polynuclear, or polyploidy CMs. De-differentiation signals together with extracellular matrix (ECM) re-organization then regulate the generation of putative de-differentiated CMs, which have evident changes in mitochondrial morphology, disassembled sarcomeres, and reduced cell adhesion. Finally, reprogramming signals and mitogens drive the formation of putative progenitors and cell division

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

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Acknowledgments
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