Fig. 8
Transplantation of Cav1-transfected caudal-SrRCs improved neuronal regeneration of adult zebrafish post-SCI. Locomotion test of SCI-adult fish during neuronal regeneration from 6 days post-transplantation (dpt) to 14 dpt. (a) The locomotive route of each fish was tracked in line, (b) its swimming distance (cm) was calculated, and the results were compared among non-treated WT-adult (WT; positive control), SCI-adult (SCI-only; negative control), rostral-SrRCs-transplanted SCI-adult, caudal-SrRCs-transplanted SCI-adult and Cav1-caudal-SrRCs-transplanted SCI-adult in which SCI adults were transplanted with caudal-SrRCs transfected by cav1. Two-way ANOVA and t-test were used to perform statistical analysis with different significance level at ***p < 0.001, **p < 0.05, *p < 0.01; error bars indicate s.e.m. |