FIGURE

Figure 5

ID

ZDB-FIG-210210-36

Publication

Soliman et al., 2021 - l-Isoaspartyl Methyltransferase Deficiency in Zebrafish Leads to Impaired Calcium Signaling in the Brain

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Figure 5

Knockdown of pcmt and pcmtl leads to morphological changes and developmental delay. The morphological changes were ranked from mild to severe in 2 dpf larvae [(A–D); trunk curvature and decreased pigmentation) and in 4 dpf larvae (E–H); lack of the swim bladder, body curvature, and strong malformation]. Relative quantification of these phenotypes was performed by observation of the indicated numbers of pcmt/l morphants compared to control and rescue larvae (exogenous expression of pcmt/l via mRNA or Tol2 transgenesis in the morphant background) at 2 dpf (I) and 4 dpf (J). Arrows indicate the internal brain structure showing smaller brain size in the pcmt/l morphant larvae (L) compared to control MO-injected larvae (K).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO2-pcmt + MO2-pcmtl
Knockdown Reagents:	MO2-pcmt MO2-pcmtl
Observed In:	brain embryo development head swim bladder trunk whole organism
Stage Range:	Long-pec to Day 4

Phenotype Detail

Acknowledgments

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