FIGURE

Figure 6

ID

ZDB-FIG-210210-26

Publication

Zhang et al., 2021 - SNRNP200 Mutations Cause Autosomal Dominant Retinitis Pigmentosa

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Figure 6

Phenotypic comparison among zebrafish larvae with SNRNP200 silencing, and with overexpression of SNRNP200^WT, or SNRNP200^c.C6088T. (A) Systemic phenotype of zebrafish larvae injected with 4 ng Control-MO (control); 4 ng SNRNP200-MO (MO); 4 ng SNRNP200-MO +200 pg SNRNP200^WT mRNA (MO + SNRNP200^WT); and 4 ng SNRNP200-MO+200 pg SNRNP200^c.C6088T mRNA(MO + SNRNP200^c.C6088T). (B) phenotype distribution in four groups injected variously as shown in (A) including normal, deformed and dead ones were calculated from 1 to 3 dpf. The percentage of those are shown in the graph. Comparing with the group injected with SNRNP200-MO, the group of injection of MO + SNRNP200^WT particularly reduced the ratio of deformed and dead larvae, whereas injection of MO + SNRNP200^c.C6088T significantly raise the rate of death (34 vs. 77%, P < 0.001). Data are shown as mean + SD from technical triplicates. n: total number of larvae for each group from triple experiment. **P < 0.01, ***P < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-snrnp200
Knockdown Reagent:	MO1-snrnp200
Observed In:	whole organism
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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