FIGURE
Figure 7.
- ID
- ZDB-FIG-210208-61
- Publication
- Alyenbaawi et al., 2021 - Seizures are a druggable mechanistic link between TBI and subsequent tauopathy
- Other Figures
-
- Figure 1
- Figure 1; supplement 1.
- Figure 1; supplement 2.
- Figure 1; supplement 3.
- Figure 2.
- Figure 3
- Figure 3; supplement 1.
- Figure 4.
- Figure 5
- Figure 5; supplement 1.
- Figure 5; supplement 3.
- Figure 5; supplement 4.
- Figure 5; supplement 5.
- Figure 5;supplement 2.
- Figure 6
- Figure 6;supplement 1.
- Figure 7.
- All Figure Page
- Back to All Figure Page
Figure 7.
Tauopathy was reported via aggregation of a genetically encoded chimeric protein, Tau4R-GFP, that was expressed throughout the central nervous system. TBI led to seizures, and subsequently to Tau aggregation and cell death (akin to chronic traumatic encephalopathy, CTE). The tauopathy and cell death were ameliorated, producing healthy larvae, by blocking seizures with anti-convulsants; these effects were specific insomuch that they could be reversed by co-application of convulsants. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ Elife