FIGURE

Fig. 2

ID

ZDB-FIG-210204-29

Publication

Tingaud-Sequeira et al., 2020 - Functional and genetic analyses of ZYG11B provide evidences for its involvement in OAVS

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Fig. 2

The nonsense variant encodes a mislocalized truncated ZYG11B protein. (a) Western blot validated overexpression experiments. (b) Immunocytochemistry detection of ZYG11B?WT and ZYG11B?E537* in HeLa cells. (c) RT?qPCR experiments validated ZYG11B expression knockdown by the specific siRNA?ZYG11B which also induced a significant down?regulation of SOX6 expression, t test p < .05. (d) Cell proliferation is significantly decreased when treated with siRNA?ZYG11B (Kruskal?Wallis test followed by Dunns? post hoc multiple comparison test (p < .05)). (d) RT?qPCR analysis of ZYG11B expression showed a down?regulation following RA treatment in HeLa cells (t test p < .05)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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