FIGURE

Fig. 7

ID

ZDB-FIG-210203-22

Publication

Rauschenberger et al., 2020 - GlyR autoantibodies impair receptor function and induce motor dysfunction

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Fig. 7

All patient sera target some GlyR subunits of the zebrafish. HEK293 cells cotransfected with green fluorescent protein (GFP; cyan) and GlyR subunits of Danio rerio (dr; α1, α2, α3, α4a, α4b, βa and βb) were stained with sera from Patient 2 (pat2), pat3, pat4, pat5, and pat6 (red). 4,6‐Diamidino‐2‐phenylindole (DAPI) (blue) labeled the nucleus. White bar in right column represents 20μm. Note that most patient sera target α2, α3, and α4a. The β subunits of D. rerio do not represent a common target for the human GlyR autoantibodies. Stainings for the β subunits were performed following permeabilization of the cells, because the β subunits are not transported to the surface without the presence of α subunits.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Ann. Neurol.